Immune checkpoints and the HIV-1 reservoir: proceed with caution
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چکیده
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Immune checkpoints and the HIV-1 reservoir: proceed with caution
Successfully identifying and targeting immune checkpoints on latently HIV-1-infected CD4 T cells could be a key component in HIV-1 eradication therapies [1,2]. Immune checkpoints are negative regulators of: (i) T cell activation; (ii) T cell proliferation; and (iii) effector functions including cytokine production [3]. Thus, inhibiting immune checkpoints could influence the resting status of la...
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ژورنال
عنوان ژورنال: Journal of Virus Eradication
سال: 2016
ISSN: 2055-6640
DOI: 10.1016/s2055-6640(20)30463-5